WILLIAM CHARLES HOWLAND III, M.D.

11645 Angus Rd A1

Austin, Texas 78759

(512) 345-7635

CURRENT POSITION

Private Practice 8/1991 to Present Allergy and Asthma Center of Austin

Austin, Texas

Medical Director 01/2018 to present Orion Clinical Research

Austin, Texas

PAST POSITIONS

Medical Director 12/2009-2016  Sirius Clinical Research

Austin, Texas 

Medical Director Lovelace Research

Austin, Texas site

Private Practice Allergy and Asthma Centre

St. Petersburg, Florida

Allergy and Asthma Associates

Columbia, South Carolina

Clinical Assistant Professor  Internal Medicine and Pediatrics

School of Medicine

University of South Carolina

Medical Director HealthQuest Therapy and Research Institute

Austin, Texas 

Clinical Investigator CEDRA Research

Austin, Texas

PROFESSIONAL EXPERIENCE

Fellowship Allergy and Immunology

Scripps Clinic and Research Foundation

La Jolla, California

July 1984-June 1986

Chief Clinical Fellow

Scripps Clinic and Research Foundation 

La Jolla, California

June 1985-January 1986

Residency Internal Medicine

Scott and White Memorial Hospital

Temple, Texas

 July 1982-June 1984

Internship Internal Medicine

Tulsa Medical College

University of Oklahoma

July 1981-June 1982

EDUCATION

Medical School M.D. – University of Texas Medical Branch

Galveston, Texas – May 1981

Undergraduate General Comparative Studies, Plan II

University of Texas, Austin – May 1977

Honors Graduated Magna Cum Laude with Special Honors Plan II 

University of Texas, Austin – May 1977

Membership in Phi Beta Kappa Honor Society

University of Texas, Austin – May 1977

PROFESSIONAL DATA

Date of Birth January 19, 1955; Huntsville, Alabama

Family  Wife-Cynthia; Son-Billy; Daughter-Christy

Outside Interests Guitar, bass, and other musical instruments, photography, family activities

PUBLICATIONS

Howland WC: Fluticasone propionate: topical or systemic effects? Clin Exp All 1996;26(3):18.

Howland WC, Simon, RA: Sulfite-treated lettuce challenges in sulfite-sensitive subjects 

with asthma. J Allergy Clin Immunol 1989;83(6):1079.

Ferreri NR, Howland W, Stevenson DD, Spiegelber HL: Release of leukotrienes, prostaglandins,

and histamine into nasal secretions of aspirin-sensitive asthmatics during reaction to aspirin. Ann

Rev Respir Dis 1986;137(4):847.

Ferreri NR, Howland WC, Spiegelberg HL: Release of leukotrienes C4 and B4 and

prostaglandin E2 from human monocytes stimulated with aggregated IgG, IgA, and IgE. 

J Immunol 1986;136(11):4418.

Lang DM, Howland WC: Solar sneeze reflex. JAMA 1987;257(10):1330. Letter.

Bernstein DI, Creticos PS, Busse WW, Cohen R, Graft DF, Howland WC, et al: Comparison of 

triamcinolone acetonide nasal inhaler with astemizole in the treatment of ragweed-induced

allergic rhinitis. J Allergy Clin Immunol 1996;97(3):749.

Berkowitz RB, Dockhorn R, Lockey R, Findlay S, Howland WC, Mitchell DQ, Woehler T: 

Comparison of efficacy, safety, and skin test inhibition of cetirizine and astemizole. Ann Allergy 

1996;76(4):363.

Howland WC, Dockhorn R, Gillman S, Gross GN, Hille D, Simpson B, Furst JA, Feiss G, Smith

JA: A comparison of effects of triamcinolone acetonide aqueous nasal spray, oral prednisone,

and placebo on adrenocortical function in male patients with allergic rhinitis. J Allergy Clin

Immunol1996;98(2)302.

Prenner BM, Chervinsky P, Hampel FC, Howland WC, Lawrence M, Meltzer EO, Munk ZM

Ratner PH, Seltzer JM, Settipane GA, Lorber RR, Harrison JE: Double-strength beclomethasone

dipropionate (84mcg/spray) aqueous nasal spray in the treatment of seasonal allergic rhinitis.

J Allergy Clin Immunol 1996;98(2):302.

Howland WC, et al: The efficacy of fluticasone propionate aqueous nasal spray for allergic

rhinitis and its relationship to topical effects. Clin Therapeutics 18:6.

Weinstein S, Chervinsky P, Pollard SJ, Bronsky EA, Nathan RA, Prenner B, Howland WC, Stahl

E, Liddle R,: A one-week dose-ranging study of inhaled salmeterol in children with asthma. 

J Asthma 1997;34(1):43.

Juniper EF, Howland WC, Roberts NB, Thompson AK, King DR, Math B: Measuring quality of

life in children with rhinoconjunctivitis. J Allergy Clin Immunol 101:(2)(1)163.

Nathan RA, Mason J, Bernstein DI, Howland WC, Kaiser HB, Meltzer EO, Segall N:

Long-Term Tolerability of Fexofenadine in Healthy Volunteers. Clin Drug Invest 1999

Oct;18(4):317-328.

Dockhorn R, Aaronson D, Bronsky E, Chervinsky P, Cohen R, Ehtessabian R, Finn A,

Grossman J, Howland W, Kaiser H, Pearlman D, Sublett J, Ratner P, Settipane G, Sim T, 

Storms W, Webb R, Drda K, Wood C: Ipratropium bromide nasal spray 0.03% and 

beclomethasone nasal spray alone in combination for the treatment of rhinorrhea in perennial

rhinitis. Ann Allergy Asthma Immunol 1999 Apr;82(4):349-59.

Tashkin DP, Nathan RA, Howland WC, Minkwitz MC, Simonson SG, Bonuccelli CM: An

evaluation of zafirlukast in the treatment pf asthma with exploratory subset analyses. J Allergy

Clin Immunol 99;103:246-254.

Howland III WC, Lang DM, “Exercise and Rhinitis,” Allergic and Respiratory Disease in Sports 

Medicine, New York, NY: Marcel Dekker, Inc., 1997. 197 pp.

Banov CH, Howland III WC, Lumry WR: Once-daily budesonide via Turbuhaler improves

symptoms in adults with persistent asthma. Ann Allergy Asthma Immunol 2001 

June;86(6): 627-32.

Lang DM, Visintainer PF, Howland III WC, Stein M, Villareal M: Survey of the Extent and

Nature of Care for Adults and Older Adults by Allergy/Immunology Practitioners. Ann Allergy

Immunol 2000 Aug;85(2):106-109.

Ratner PH, Howland III WC, Arastu R, Philpot EE, Klein KC, Baidoo CA, Math M, Faris MA,

PharmD, Rickard KA: Fluticasone propionate aqueous nasal spray provided significantly greater 

improvement in daytime and nighttime nasal symptoms of seasonal allergic rhinitis compared

with montelukast. Ann Allergy Asthma Immunol 2003

ABSTRACTS

Howland WC, Simon RA: Restaurant-provoked asthma: sulfite sensitivity. J Allergy Clin

Immunol 75(1):45. Abstract.

Howland WC, Mathison DA, Fantozzi RD, Stevenson DD: Sinus surgery (ss) in aspirin sensitive 

asthmatic patients (asap). Ann Allergy 56:518. Abstract.

Ferreri NR, Howland WC, Spiegelberg HL: Release of leukotrienes C4 and B4 (LTC4, LTB4)

and prostagladin E2 (PGE2) from human monocytes (Mo) induced wth aggregated

immunoglobulines (Ig) of different classes. Abstract presented at FASEB National Meeting,

April 1986. 

Lang DM, Howland WC, Stevenson DD: Sensitivity and features of nasal cytology in diagnosis

of allergic (IgE-mediated) rhinitis. Ann Allergy 60:176. Abstract.

Hampel F, Howland W, Martin B, et al. The efficacy of fluticasone propionate aqueous nasal

spray for treatment of rhinitis is dependent on topical application. J Allergy Clin Immunol

93:165. Abstract.

Howland W, Segal A, Glass M, Minkwitz, ZENECA Pharmaceuticals Group: 6-Week Therapy

with the oral leukotriene-receptor antagonist, ICI 204,219,in the treatment of asthma. J Allergy

Clin Immunol 93:581. Abstract.

Prenner B, Chevinsky P, Hampel FC, Howland WC, Lawrence M, Meltzer FO, Munk ZM,

Ratner PH, Seltzer J, Settipane GA, Lorber RL, Harrison JE: Double strength beclomethasone

dipropionate (84mcg/spray) aqueous nasal spray in the treatment of seasonal allergic rhinitis

(SAR). J Allergy Clin Immunol 95:218. Abstract.

Howland W, Field E, Harding S, Rogenes P, Pobiner B, Scott C, Milwee S, Hamedani A:

Fluticasone propionate aqueous nasal spray (fpans) is an anti-rhinitic with topical but not

systemic activity. J Allergy Clin Immunol 95:221. Abstract.

Shapiro G, Nathan R, Noonan M, Taylor J, D’Alonzo G, Busse B, Howland W, Simon R, 

Robison A, Blosch C: Recombinant human 1L-1R (rhu 1L-1R) in adult patients with mild to 

moderate asthma. J Allergy Clin Immunol 95:848. Abstract.

Storms W, Howland WC, Sorkness CA, LaForce C, Goldstein M, Lincourt WR, Rogenes PR,

Schaberg AE, Edwards L, FP HPA Axis Clinical Study Group: Fluticasone propionate (FP), 

triamcinolone acetonide (TAA) and Flunisolide (FLN) have similar effects of the HPA axis. J

Allergy Clin Immunol 99:1304. Abstract.

Howland W, Birdsall D, Uryniak T, Casty FE, Intal Study Group: A twelve week placebo-

controlled efficacy and safety study of Intal 1 mg formulated with CFC or HFA-227 as

propellant for the treatment of asthma. J Allergy Clin Immunol 99:1321. Abstract.

Ratner PH, vanBavel JH, Martin BG, Hampel FC, Howland WC, Rogenes PR, Westlund R, 

Cook CK: The efficacy and safety of fluticasone propionate (FP) aqueous nasal spray and

loratadine (LOR), alone and in combination, in the treatment of seasonal allergic rhinitis (SAR).

J Allergy Clin Immunol 99:1784. Abstract.

Bowers B, Cox F, Howland W, Cook C, Westlund R, Rogenes P: Superior impact of intranasal 

fluticasone vs loratadine on work, home & leisure activities affected by SAR. J Allergy Clin

Immunol 99:1785. Abstract.

Finn AF, Howland WC, Bronsky EA, Lumry WR, Pepsin PJ, Rogenes PR, Westlund R, 

Cook CK: The efficacy of three different dosig regimens of fluticasone propionate (FP) aqueous

nasal spray in the treatment of perennial nonallergic rhinitis (PNAR). J Allergy Clin Immunol

99:1787.Abstract.

Pepsin PJ, Howland WC, Finn AF, Cox FM, Bowers BW, Montgomery E, Westlund R: Patient-

related overall treatment satisfaction and effectiveness with three dosing regimens of intranasal

fluticasone propionate (FP) in perennial non-allergic rhinitis (PNAR). J Allergy Clin Immunol 

99:1796. Abstract.

Weinstein S, Chervinsky P, Pollard SJ, Bronsky EA, Nathan RA, Prenner B, Howland WC, 

Stahl E, Liddle R: A one-week dose-ranging study of inhaled salmeterol in children with asthma.

J Asthma 34(1);43. Abstract.

Tashkin DP, Nathan RA, Howland III WC, Minkwitz MC. Efficacy of zafirlukast (Accolate):

exploratory subset data from three 13-week multicenter trials. Am J Resp Critical Care Med 

155:663. Abstract.

Howland III W, Kemp J, McClung G, Arledge T, Byrne A, St Cyr C, Stahl E. Salmeterol in the

Diskus powder inhaler is effective and well tolerated in protecting against exercise-induced

bronchospasm (EIB) in adolescents and adults with asthma. Am J Resp Critical Care Med 

155:962. Abstract.

Tita J, LaForce C, Howland III WC, Noveck RJ, Tripathy I, Reed KD, Edwards LD, Schaberg A,

Rogenes P. Use of 6-hr cosyntropin stimulation tests to evaluate potential effects of inhaled

fluticasone propionate (FP), inhaled triamcinolone acetonide (TAA), placebo (PBO), and oral

prednisone on HPA axis function. Am J Resp Critical Care Med 155:355. Abstract.

Harrison LI, Soria I, Machacek J, Jacobson J, Purrington A, Cline A, Grassell J, Dahl D, 

Wells T, Chang S, Howland W. Pharmacokinetic profile of improved drug delivery with CFC

free ultrafine aerosol steroid inhaler. Am J Resp Critical Care Med 155:666. Abstract.

Harrison L, Soria I, Machacek J, Jacobson J, Purrington A, Cline A, McCarville S, Grassell J,

Dahl D, Wells T, Chang S, Howland W. Pharamacokinetics of beclomethasone dipropionate

from CFC-free ultrafine aerosol and conventional CFC inhalers in asthmatics. Thorax

1996;51(3):P193. Abstract.

Harrison L, Soria I, Machacek J, Jacobson J, Purrington A, Cline A, McCarville S, Grassell J,

Dahl D, Wells T, Chang S, Howland W. Beclomethasone pharmacokinetics in asthmatics given

CFC and CFC-free inhalers. European Resp J 19969(23):256s. Abstract.

Harrison L, Soria I, Cline A, Wells T, Chang S, Howland W: 200 mcg extrafine HFA

beclonethasone dipropionate (HFA-BDP) demonstrates absorption similar total to 400 mcg of

CFC-BDP. J Allergy Clin Immunol 101:(1)(2)S65.

Howland III WC, Pepsin PJ, Westlund R, Rogenes PR, Cook CK: Gender analysis of intranasal

fluticasone propionate (FP) in patients with perennial non-allergic rhinitis (PNAR). J Allergy 

Clin Immunol 101:(1)(2) S248.

Howland III WC, Walton-Bowen K, Lampl K: Once-daily budesonide (Pulmicort 

Turbuhaler (R)) is safe and well tolerated in adult asthmatics with or without previous inhaled

corticosteroid (ICS) use. ACAAI 1999. Ann Alllergy 2000; 84(1):161.

Shapiro GG, Howland III WC: Once-daily budesonide inhalation powder (Pulmicort Turbuhaler) 

is safe and well tolerated in children previously treated with inhaled corticosteroids. J Allergy

Clin Immunol 2000; 105(No.1 Pt.2):S19.

Howland III WC, Ratner PH, Jacobs RL, Reed KD, Prillaman BA, Crim C, Cook CK:

Fluticasone propionate aqueous nasal spray relieves sinus pain and pressure in patients with

allergic rhinitis.J Allergy Clin Immunol 107:(2) S154.

van Bavel JH, Martin BG, Jacobs RL, Howland III WC, Prillaman BA, Goode-Sellers ST, Cook

CK, Richard K: #P80 Fluticasone propionate aqueous nasal spray improves snoring in patients

with sinus pain and pressure associated with nasal congestion due to allergic rhinitis. Ann

Allergy 2001;86 (1):113

Ratner PH, Howland III WC, Jacobs RL, Reed KD, Goode-Sellers ST, Prillaman BA, 

Philpot EE, Cook CK: Relief of sinus pain and pressure with fluticasone propionate aqueous

nasal spray: a placebo-controlled trial in patients with allergic rhinitis. Allergy Asthma Proc

2002;23 (4):259.

Henry, R.H., Mudaliar, S.R.D., Howland, W.C., Chu, N., Kim, D., An, B., Reinhardt, R.R.:

Inhaled insulin using the AERx insulin Diabetes Management System in healthy

and asthmatic subjects. Diabetes Care 2003; 26: 764-769..

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